Man City have been cut to a top priced 9/2 with bet365 to win their first league crown for 44 years after cutting Man United’s lead at the top of the table to five points.
Relegation-threatened Wigan, who were 7/1 to win before kick-off, secured their first-ever Premier League victory over United, while City eased past West Brom 4-0.
The 1-0 defeat leaves Sir Alex Ferguson’s men 1/5 for the title, but has boosted the Latics’ hopes of survival.
Roberto Martinez’s side are 8/11 to avoid the drop, with Bolton 4/6 to maintain their Premier League status and QPR, who hammered Swansea 3-0, now 8/15 to stay up.